SARS-CoV-2 infected subject – Communicable Diseases Research

Carriers of ADAMTS13 Rare Variants Are at High Risk of Life-Threatening COVID-19

ADAMTS13 희귀 변이의 보균자는 생명을 위협하는 COVID-19의 위험이 높습니다

Article

Published on 2022-05-292022-09-11
Journal: Viruses
[Category] COVID19(2023년), SARS, 변종,

Different decay of antibody response and VOC sensitivity in naïve and previously infected subjects at 15 weeks following vaccination with BNT162b2

BNT162b2 백신 접종 후 15주에 경험이 없는 피험자와 이전에 감염된 피험자에서 항체 반응 및 VOC 감수성의 상이한 붕괴

Research

Published on 2022-01-082022-09-10
Journal: Journal of Translational Medicine
[Category] 변종, 진단,

[키워드] administration All participants antibody Antibody Response applied assays BNT162b2 boost BTN162b2 vaccine Clinical characteristics comparable COVID-19 COVID-19 vaccine cross-neutralizing antibodies D614G demonstrated dose dropped Effectiveness ELISA enrolled expected highlight IgG Immunity infected with SARS-CoV-2 investigated Italy kinetic Kinetics Kruskal–Wallis test Mild naïve naïve subject naïve subjects neutralization assays neutralization titer Neutralizing activity Neutralizing antibodies neutralizing response outcomes pandemic Participants pseudovirus RBD-specific IgG recalled recipient reducing remained Result SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 VOCs second dose second wave sensitivity subject supplementary material the SARS-CoV-2 These data two group two groups vaccination Vaccine vaccine dose variants of concern VoC waning immunity
[DOI] 10.1186/s12967-021-03208-3 PMC 바로가기 [Article Type] Research

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection

차등 혈장 세포질 수지상 세포 표현형 및 무증상 및 심한 COVID-19 감염에서 I 형 인터페론 반응

Research Article

Published on 2021-09-022022-08-13
Journal: PLoS Pathogens
[Category] Biochemistry, SARS, 유전자 메커니즘,

[키워드] absence accompanied adaptive immune responses Anti-viral anti-viral IFN anti-viral response antiviral responses Asymptomatic asymptomatic SARS-CoV-2 infected subjects Cell cells cellular characterized chemokine chemokines circulating contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pathogenesis COVID-19 patient Critically ill Critically ill patient critically ill patients cytokine Cytokine storm Cytokines death Defense dendritic cell dendritic cells disease severity early phase elevated ENhance epithelial cells event Evidence Ex vivo expression fine-tune Frequency hospitalized patient hospitalized patients Host host defense Host-directed therapies host-directed therapy human peripheral blood mononuclear cell IFN IFN-stimulated gene Immune cell immune cells immune responses Immunity IMPROVE in vitro induce Infection Inflammatory cytokine Inflammatory cytokines inflammatory phenotype inhibiting viral replication Innate innate immune response Innate immunity Interaction interferon interferons investigated low frequency Lung epithelial cells mechanism mononuclear cell multi-organ failure neuropilin observation Pathogenesis PBMC PD-L1 marker pDC/type I IFN axis Peripheral blood pharmacological strategy phenotype plasmacytoid dendritic cell plasmacytoid dendritic cells pro-inflammatory cytokine pro-inflammatory cytokines producing productive viral replication progression protective role regulate Regulation released responsible resulting SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2 pandemic secreted secretion serum severe COVID-19 Severe COVID-19 Infection severe COVID-19 patients stratified the cytokine storm the interferon tissue damage TLR7/8 type I type I and III IFNs type I and III interferons Type I IFN type I IFN producing cells Viral viral replication Viral resistance virus viruses
[DOI] 10.1371/journal.ppat.1009878 PMC 바로가기 [Article Type] Research Article

Long-term antibody persistence and exceptional vaccination response on previously SARS-CoV-2 infected subjects

이전에 SARS-CoV-2에 감염된 피험자에 대한 장기 항체 지속성 및 탁월한 백신 접종 반응

Article

Published on 2021-07-132022-09-12
Journal: Vaccine
[Category] MERS, SARS, 진단,

Epidemiological feature, viral shedding, and antibody seroconversion among asymptomatic SARS-CoV-2 carriers and symptomatic/presymptomatic COVID-19 patients

무증상 SARS-CoV-2 보균자와 증상/전증상 COVID-19 환자의 역학적 특징, 바이러스 배출 및 항체 혈청 전환

Article

Published on 2021-07-012022-09-12
Journal: Journal of infection and public health
[Category] SARS, 진단,

[키워드] acute respiratory syndrome adaptive cellular immunity antibody antiviral immunity Asymptomatic Asymptomatic carrier Asymptomatic carriers C-reactive protein carrier carriers caused children China Cluster Clustering Comorbidities Comorbidity concerning conversion coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients enrolled enzyme-linked immunosorbent assays epidemiological Features Humoral immunity IgG IgM Immunoglobulin Infection Intra-familial transmission lymphocyte MONITOR Ningbo novel Older Older age pandemic Patient positive presymptomatic proportion SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection SARS-CoV-2. Seroconversion seropositive serum antibody severe COVID-19 severity of COVID-19 subject symptomatic symptomatic patient Transmission viral shedding White blood cell Zhejiang
[DOI] 10.1016/j.jiph.2021.05.003 PMC 바로가기 [Article Type] Article

Dynamic and features of SARS-CoV-2 infection in Gabon

가봉 SARS-CoV-2 감염의 역학 및 특징

Article

Published on 2021-05-062022-09-01
Journal: Scientific Reports
[Category] SARS, 유전자 메커니즘, 진단,

[키워드] accounted African age age distribution Ageusia Analysis analyzed Anosmia anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody Antibody Response Asthma Asymptomatic asymptomatic patient asymptomatic patients Blood Blood cells blood type Blood types calculated children chronic disease Chronic diseases clinical feature Clinical features Cohort community transmission Contact COVID-19 COVID-19 patient COVID-19 severity Critical Critical disease Critical illness cured death described diabetes diagnosed Diagnosis Disease prevention distribution driving dynamic Dyspnea Epidemiology feature female Gabon Gender hypertension Infection infection rate Influenza influenza-like symptom Influenza-like symptoms information leukocytes Leukocytosis leukopenia lowest lymphocyte Lymphocyte count lymphocytopenia male median Mild-to-moderate mild-to-moderate disease neutrophil neutrophilia neutrophilic leukocytosis Neutrophils Outcomes research participant Patient positive positive patient proportion provided public health rate of infection recorded representing Respiratory failure RT-PCR SARS-CoV-2 SARS-CoV-2 infected subject SARS-CoV-2 infected subjects SARS-COV-2 infection SARS-CoV-2 RT-PCR screened Spectrum subclinical infection Treatment protocol White blood cell White blood cells
[DOI] 10.1038/s41598-021-87043-y PMC 바로가기 [Article Type] Article

SARS-CoV-2 Viral Load, IFNλ Polymorphisms and the Course of COVID-19: An Observational Study

Article

Published on 2020-10-152022-10-30
Journal: Journal of Clinical Medicine
[Category] COVID-19,

[키워드] 95% CI Affect age and sex Asymptomatic clinical outcomes correlation Course COVID-19 COVID-19 outcomes defined disease severity enrolled homozygous Hospitalization Host IFNλs IFNL3 IFNL4 IFNλ interferon investigated laboratory-confirmed SARS-CoV-2 infection load modulate multiorgan disease mutant nasal nasopharyngeal swabs outcome outcomes Patient PCR PCR cycle pharyngeal polymorphism risk SARS-CoV-2 SARS-CoV-2 infected subject SARS-COV-2 infection significantly lower Single nucleotide polymorphism single nucleotide polymorphisms Sociodemographic statistically subject Support threshold threshold value variable viral infection Viral load were assessed
[DOI] 10.3390/jcm9103315 PMC 바로가기 [Article Type] Article